Halting Antiseizure Treatment Poses No Hurt in Infants


Sustaining antiseizure medication in infants who’ve had acute symptomatic neonatal seizures has been commonplace observe, however a potential, observational, comparative effectiveness research calls that observe into query, offering proof that discontinuing remedy at discharge poses no hurt to youngsters and has no impact on the event of epilepsies.

Dr Hannah Glass

“The stability of proof helps discontinuing antiseizure treatment after decision of acute symptomatic neonatal seizures and earlier than discharge house from the neonatal seizure admission,” stated Hannah C. Glass, MDCM, MAS, of the College of California, San Francisco, Benioff Youngsters’s Hospital, co-principal investigator, who offered outcomes of the research on the 2020 CNS-ICNA Conjoint Assembly, held nearly this 12 months. Renee Shellhaas, MD, MS, scientific affiliate professor of pediatrics at C.S. Mott Youngsters’s Hospital, College of Michigan, was the opposite co-principal investigator.

Dr Renee Shellhaas

“Though different, smaller research have recommended it’s secure to discontinue antiseizure treatment after decision of acute symptomatic seizures, the observe of early discontinuation has been very variable and relies upon largely on particular person supplier choice,” Glass stated in an interview. “In our research, two-thirds of newborns with acute symptomatic seizures had been maintained on antiseizure treatment on the time of hospital discharge. Thus, a change to early treatment discontinuation represents a serious shift.”

The research evaluated 270 infants at 9 facilities enrolled within the Neonatal Seizure Registry and born from July 2015 by way of March 2018. Inclusion standards had been acute symptomatic seizures that occurred at as much as 44 weeks postmenstrual age. On this cohort, 36% of sufferers had antiseizure treatment discontinued after a median of 6 days; the rest stayed on antiseizure treatment after discharge at a median of 4 months.

The sufferers had been adopted for two years. The first final result was useful improvement measured by the Warner Preliminary Improvement Analysis of Adaptive and Purposeful Expertise (WIDEA-FS) evaluation. The secondary final result was epilepsy outlined by Worldwide League Towards Epilepsy (ILAE) standards. Observe-up consisted of cellphone calls and chart critiques at 12, 18, and 24 months.

“The first final result, useful improvement, was not considerably totally different between these youngsters who had been maintained on antiseizure treatment as in contrast with those that had been discontinued,” Glass stated.

After propensity adjustment, the discontinued ASM group had an estimated WIDEA-FS rating 4 factors increased on common, she stated. “The arrogance intervals met our a priori noninferiority restrict, indicating no hurt to neurodevelopment for discontinuing antiseizure treatment earlier than discharge house from the neonatal seizure admission,” Glass famous.

The research additionally discovered that 13% of all members developed epilepsy at a median of 8 months. “There was no vital distinction within the frequency or timing of epilepsy between the 2 teams,” she stated.

“We conclude there isn’t a clear rationale for antiseizure treatment upkeep,” Glass stated. “There isn’t a profit to neurodevelopment, it prolongs the publicity to doubtlessly dangerous antiseizure drugs, it doesn’t considerably delay the onset of epilepsy, and the earliest-onset epilepsies happen regardless of antiseizure treatment.”

The Affected person-Centered Outcomes Analysis Institute (PCORI) and Pediatric Epilepsy Analysis Basis funded the research. Glass has no different monetary relationships to reveal.

SOURCE: Glass HC et al. CNS-ICNA 2020. Presentation PL58.

This text initially appeared on MDedge.com, a part of the Medscape Skilled Community.